alexanderwerk wp120 screw speed

Bonding Mechanisms Involved in the Roller Compaction …

2 | P a g e Abstract Roller compaction is a dry agglomeration process which uses high stresses to bond powder particles together to form an agglomerate

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(203c) Understanding Critical Parameters in Roller ...

 · They were roller compacted at a wide range of roll pressures and roll gaps on Alexanderwerk® WP120, Alexanderwerk® WP200 and a costumer-built instrumented roller compactor. The normal and shear stresses during the process at different conditions were measured via a roller instrumented with strain gages on roll surface across roll width.

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Mechanistic Insights into the Scale‐Up of the Roller ...

 · Therefore, in order to produce a placebo ribbon of similar density on the Alexanderwerk® WP200, c s N s N R on the Alexanderwerk® WP200 should be three times greater than that for the Alexanderwerk® WP120, assuming roll gap, S, is to be kept constant ( γ 0 and ρ true are constant for the same material).

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Roller compaction process development and scale up using ...

 · While WP120 has a single screw speed, WP200 is equipped with a twin feed screw system. Due to twin feed screw vs. single feed screw difference, the normal stress profile on WP200 is quite different from the one obtained on WP120. ... available for the Alexanderwerk ® WP120 …

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BT 120 Pharma

BT 120 Pharma: Compaction machine for laboratory and special purpose With the introduction of the BT 120 Pharma, Alexanderwerk oers a roller compactor designed to meet the highest requirements and standards in pharmaceutical research and development. With a throughput of up to 8 kg/h (Lactose), the BT 120 Pharma can be used for granulation of biological compounds and active ingredients.

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Development of Common Formulations for Both …

on an Alexanderwerk WP120 roller compactor set at 5 rpm roll speed, 30 bar roll pressure, 36 rpm feed screw speed and 2 mm roll gap. The tableting operation was conducted on a 10-station instrumented Piccola tablet press at 30 rpm, and the HQFDSVXODWLRQRQDRQDWDPS ¿OOLQJPDFKLQH,Q &DS ''RWW %RQDSDFH& Z LWKD W KURXJKSXWR I F DSVXOHV KRXU

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Changquan Calvin Sun Lab | College of Pharmacy ...

Roller compactor (Alexanderwerk, WP120) Fully instrumented (feed screw speed, roll pressure, roll gap, milling speed, vacuum) Micro batch (5-10g batch size) Other Instruments . Powder characterization. Helium pycnometer; Atomic force microscope (AFM) Particle size analyzer;

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Pharmaceutics | Free Full-Text | Model-Based Scale-up ...

where C S is the screw speed constant, ... A study comparing the density results of actual experiments using the FEM model and the Alexanderwerk WP120 roll compactor (Alexanderwerk , Germany) was conducted. To improve the accuracy of the model, the boundary conditions of the model were determined using experimentally measured values. ...

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Narrowing the gap between clinical capsule formulations ...

compactor (Alexanderwerk WP120; Alexanderwerk Inc., PA, USA) set at 5 rpm roll speed, 30 bar roll pressure, 36 rpm feed screw speed and 2 mm roll gap. The ribbons were milled through a Quadro Comil U5 (Quadro, Canada) set at 1500 2500 rpm impeller speed and using a 0.050 0.079 in. grater screen. The resulting granules were then

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Quality by Design I: Application of Failure Mode Effect ...

 · Granulation was performed using a fixed roll-gap of 1.5 mm. Studies carried out previously (7–9) have shown that there is no significant differences in the physical–mechanical properties of roller-compacted products processed at different feed screw speed (FSS) and roller speed (RS) settings if the ratios were kept constant; therefore, for ...

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Vishwas Nesarikar

Instrumented roll technology on Alexanderwerk WP120 roller compactor was developed and utilized successfully for the measurement of normal stress on ribbon during the process.

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Alexanderwerk Roller Compactor, Model WP120V PHARMA ...

Item Details. Used Alexanderwerk roller compactor, model WP120 V PHARMA, stainless steel construction, horizontal screw feeder with pre breaker, cantilevered rolls, flake crusher, pre granulator and fine granulator attachments, rated +/- 5g batch, 8 - 40 kg/hour continuous operation with operator control panel, portable design, 460 volt, serial ...

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Control performance of different roll compactors

 · The AlexanderWerk roll compactor does not have any control system, thus the gap width was dependent on the screw speed and roll speed. The hydraulic pressure was adjusted by the hydraulic system. The BRC 25 set the specific compaction force through a spindle motor [6], while the gap size was controlled by a PI control system.

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Buy and Sell Used Compactor Densifier | Perry Process ...

5″ X 7″ Alexanderwerk Line For Compacting Powders. Stock #U2064. Used line for compacting powders by Alexanderwerk (Germany). Line consists of: – feeding system – includes: 50 l powder container, rotary valves, vacuum pump, piping and bag filter. – horizontal, twin screw, feeder with adjustable working speed in range 0-77...

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Continuous Dry Granulation by Roller ...

 · feed screw. For most materials, when the feed screw is working ideal ly, the throughput of the machine increases linearly with the feed screw speed. Besides that, the feed screw speed determines the size of the roller gap when pressure and roller speed …

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Alexanderwerk WP120Pharma Roller Compactor, S/S | Federal ...

Material of Construction: Stainless Steel. Model/Type: WP120Pharma. Roll diameter: #": 120. Roll Surface (List): Smooth / Grooved: smooth. Serial Number: 900-1126. Year of Construction: 2016. Terms & Conditions. Federal Equipment Company makes reasonable efforts to ensure accuracy of the information we provide.

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Continuous Dry Granulation by Roller ...

increases linear lywith the feed screw speed. Besides that, the feed screw speed determines the size of the roller gap when pressure and roller speed are constant. Therefore, the roller gap can be kept constant by a PID-controlled roller-gap-control that automatically adjusts the feed screw speed.

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alexanderwerk used machine for sale

 · - intermediate tank with screw type agitator, working with adjustable speed in range 0-20 rpm. - roll compactor ALEXANDERWERK model WP170/120V, designed in stainless steel. Machine has two rolls, each with width 120 mm x diameter 170 mm, mounted vertically. Rolls are working with adjustable speed in range 0-20 rpm.

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(PDF) Investigating the influence of moisture content and ...

Ribbon productionThe equilibrated powder was compressed into a ribbon using an Alexanderwerk WP120 (Alexanderwerk, Germany) roller compactor. The WP120 is a horizontally screw fed roller compactor that uses side cheeks to prevent the powder from …

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Quality-by-Design II: Application of Quantitative Risk ...

Alexanderwerk® WP120 roller compactor and a Stokes B2 tablet press; the conditions and results of these studies are shown in F1–F42, in the supplemental spreadsheet. The sec-ond arm (study 2b) used identical conditions except that a different Alexanderwerk® WP120 roller compactor and a different Stokes B2 tablet press were used at a ...

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WP 120 Pharma

WP 120 Pharma: Laboratory and pilot production machine for the pharmaceutical industry With the introduction of the WP 120 Pharma, Alexanderwerk oers a roller compactor designed to meet the highest requirements and standards in pharmaceutical research and development. On this machine small amounts of as little as 5 g to a maximum up to 40 kg/h (Lactose) can be processed with the standard ...

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Orthos Engineering – Alexanderwerk WP120 laboratory roller ...

Alexanderwerk''s WP120 laboratory roller compactor is an all-in-one dry granulation machine for producing free flowing granules to feed your capsule filler or tablet press. Pre-blended powder is fed into the raw material hopper where a slow turning agitator encourages its flow into the horizontal screw …

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Continuous manufacturing & robust process control for …

Roller Compactor: Alexanderwerk WP120 Tablet Press: Natoli BLP‐16, Natoli NP‐400. 12/16/2018 8 15 Layer 2 ... rate by manipulating the fill depth and turret speed. 18 Natoli BLP‐16 Mettler Toledo ...

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Stage 3

Alexanderwerk WP120 with 25 mm roller width and 120 mm roller diameter ... •Screw Speed and Roll Speed •Mill Screen Size and Mill Speed Scale Model Roller width (mm) Roller diameter (mm) Roller Gap (mm) Roller Pressure (bar) Mill screen orifice (mm) Lab WP120 25 120 1.2-2.4 20-77 1.0 Pilot WP120 40 120 1.8 50 1.0 Commercial WP200 75 200 2.0 ...

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WP 120 Pharma | Alexanderwerk | The Compaction Family

WP 120 PHARMA. The WP 120 Pharma was specially designed by Alexanderwerk for use in pharmaceutical research and development areas, where it meets the highest requirements and standards. Minimum product quantities from 1 g as well as throughputs of up to 50 kg/h (basing on lactose) can be processed with the standard roller width of 40 mm into ...

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Used

Used- Alexanderwerk Roller Compactor, model WP120V Pharma, stainless steel. Horizontal screw feeder with pre-breaker, cantilevered rolls, flake crusher, pre-granulator and fine granulator attachments, rated +/- 5g batch, 8 - 40 kg/hour continuous, Siemens Simatic multi panels operation with operator control panel, portable design, unit designed for soft wall isolator with framework, machine # ...

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Instrumented roll technology for the design space ...

Instrumented roll technology on Alexanderwerk ® WP120 roller compactor was developed and utilized successfully for the measurement of normal stress on ribbon during the process. The effects of process parameters such as roll speed (4–12 rpm), feed screw speed (19–53 rpm), and hydraulic roll pressure (40–70 bar) on normal stress and ribbon density were studied using placebo and active ...

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Alexanderwerk Roller Compactor, Model WP120

One used Alexanderwerk Roller Compactor, Model WP120, Serial 900-0021, built 2006, stainless steel construction, horizontal screw feeder with pre breaker, cantilevered rolls, flake crusher, pre granulator and fine granulator attachements, rated +/- 5g batch, 8 - 40 kg/hour continuous, Siemens Simatic multi panels operation with operator control panel, portable design, unit designed for soft ...

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Real-time Exceptional Events Management for a Partial ...

 · The resulting powder blend is subsequently fed into an Alexanderwerk WP120 × 40 roller compactor that compacts the blend into ribbons ... The roller compactor variables of feed screw speed, roll speed, and hydraulic pressure were, respectively, set to 26 rpm, 6 rpm, and 30 bar. When gap controller was enabled, roll gap was fixed to 2 mm—this ...

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Implementation of an online thermal imaging to study the ...

the screw feeder speed, which increased to feed additional powder as required to adjust to the change in process parameters. ... An Alexanderwerk WP120 (Alexanderwerk, Germany) roller ... The WP120 has three systems working simulta-neously: the feeding system, compaction system and milling system. The feeding system consists of a hopper for the ...

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Pharma Compactors

Alexanderwerk Kippdorfstr. 6-24 42857 Remscheid/Germany P +49 (0) 2191 7950 F +49 (0) 2191 795350 [email protected] No liability is taken for errors, prin ng errors and technical changes. Alexanderwerk roller compactors for the pharmaceu cal industry Compac on machine Roller compactor BT 120 Pharma

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Instrumented roll technology for the design space ...

 · Instrumented roll technology on Alexanderwerk ® WP120 roller compactor was developed and utilized successfully for the measurement of normal stress on ribbon during the process. The effects of process parameters such as roll speed (4–12 rpm), feed screw speed (19–53 rpm), and hydraulic roll pressure (40–70 bar) on normal stress and ribbon density were studied using placebo …

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